A rift that has opened up between basic research (bench) and clinical research and patients
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …

There is considerable evidence that the translation rate of major basic science promises to
clinical applications has been inefficient and disappointing. The deficiencies of translational …

Translational medicine is the integrated application of innovative pharmacology tools,
biomarkers, clinical methods, clinical technologies and study designs to improve disease …

On the basis of our experience in drug and device development, we have identified six
broad categories of issues that profoundly affect the probability for successful translation of …

Highlights•Innovative 21st-century roadmaps need to be devised for biomedical
research.•Advanced human biology-based models and tools hold the key to …

In the first week of October, I announced the launch of a national consortium that will
transform how clinical and translational research is conducted; ultimately enabling …

Over the past 20 years, pharmaceutical companies have implemented conservative
management practices to improve the predictability of therapeutics discovery and success …

Our modern health care system demands therapeutic interventions that improve the lives of
patients. Unfortunately, decreased productivity in therapeutics research and development …

Traditional boundaries among basic research, clinical research and patient-oriented
research are yielding to a single, continuous, bidirectional spectrum commonly …

Clinical and translational science has emerged as the cornerstone of biomedicine poised to
actualize, during this decade, the healthcare value of national investments that fuel the …