How do adverse childhood experiences get 'under the skin'and influence health outcomes
through the life-course? Research reviewed here suggests that adverse childhood …

Adversity in childhood has effects on mental and physical health, not only in childhood but
across the lifespan. A chief task of our research has been to define the pathways by which …

Background Adverse psychosocial exposures in early life, namely experiences such as child
maltreatment, caregiver stress or depression, and domestic or community violence, have …

Childhood adversity has been repeatedly and robustly linked to physical and mental illness
across the lifespan. Yet, the biological pathways through which this occurs remain unclear …

Childhood maltreatment represents a significant risk factor for the development of a number
of mental and physical health outcomes. Converging evidence suggests that early adversity …

Abstract Adverse Childhood Experiences (ACEs) are stressful and/or traumatic experiences
associated with an increased lifetime risk of negative health outcomes. The Allostatic Load …

An increasing prevalence of early childhood adversity has reached epidemic proportions,
creating a public health crisis. Rather than focusing only on adverse childhood experiences …

Childhood maltreatment has been linked to numerous negative health outcomes. However,
few studies have examined mediating processes using longitudinal designs or objectively …

Adverse childhood experiences (ACEs), such as maltreatment and severe household
dysfunction, represent a significant threat to public health as ACEs are associated with …

BACKGROUND: Retrospective studies show that childhood adversity is associated with
systemic inflammation in adulthood. Few prospective studies have examined whether …