Identification of soluble biomarkers that associate with distinct manifestations of long COVID

M Buggert, Y Gao, C Cai, S Adamo, E Biteus, H Kamal… - 2024 - researchsquare.com
Long COVID is a heterogeneous clinical syndrome of uncertain etiology triggered by
infection with SARS-CoV-2. We employed ultrasensitive approaches to profile the immune …

Persistent serum protein signatures define an inflammatory subcategory of long COVID

A Talla, SV Vasaikar, GL Szeto, MP Lemos… - Nature …, 2023 - nature.com
Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring
diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The …

[HTML][HTML] Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

C Liu, AJ Martins, WW Lau, N Rachmaninoff, J Chen… - Cell, 2021 - cell.com
COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …

[HTML][HTML] A multi-omics based anti-inflammatory immune signature characterizes long COVID-19 syndrome

JJ Kovarik, A Bileck, G Hagn, SM Meier-Menches… - Iscience, 2023 - cell.com
To investigate long COVID-19 syndrome (LCS) pathophysiology, we performed an
exploratory study with blood plasma derived from three groups: 1) healthy vaccinated …

Persistent serum protein signatures define an inflammatory subset of long COVID

A Talla, SV Vasaikar, GL Szeto, MP Lemos… - BioRxiv, 2022 - biorxiv.org
Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring
diverse symptoms that can persist for months after acute SARS-CoV-2 infection. The …

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation

P Openshaw, F Liew, C Efstathiou, S Fontanella… - 2023 - researchsquare.com
One in ten SARS-CoV-2 infections result in prolonged symptoms termed long COVID, yet
disease phenotypes and mechanisms are poorly understood. We studied the blood …

[PDF][PDF] Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2 Kailin Yin1, 2, Michael J …

SA Lee, KL Lynch, JD Kelly, JN Martin, J Münch… - scienceopen.com
Long COVID (LC), a type of post-acute sequelae of SARS-CoV-2 infection (PASC), occurs
after at least 10% of SARS-CoV-2 infections, yet its etiology remains poorly understood …

Proteomics uncovers immunosuppression in COVID-19 patients with long disease course

S Tang, R Sun, Q Xiao, T Mao, W Ge, C Huang, M Luo… - medRxiv, 2020 - medrxiv.org
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of
SARS-CoV-2 infection. Here, we present a longitudinal sera proteomic resource for 37 …

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease

F Liew, C Efstathiou, S Fontanella, M Richardson… - medRxiv, 2023 - medrxiv.org
One in ten SARS-CoV-2 infections result in prolonged symptoms termed 'long COVID', yet
disease phenotypes and mechanisms are poorly understood. We studied the blood …

[HTML][HTML] T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID

R Cezar, L Kundura, S André, JY Lefrant… - Frontiers in …, 2024 - frontiersin.org
Background As about 10% of patients with COVID-19 present sequelae, it is important to
better understand the physiopathology of so-called long COVID. Method To this aim, we …