Metacells are cell groupings derived from single-cell sequencing data that represent highly
granular, distinct cell states. Here we present single-cell aggregation of cell states …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes
severe complications and even death. However, asymptomatic infection has also been …

Although tremendous effort has been put into cell-type annotation, identification of
previously uncharacterized cell types in heterogeneous single-cell RNA-seq data remains a …

Summary Exhausted CD8 T (Tex) cells are immunotherapy targets in chronic infection and
cancer, but a comprehensive assessment of Tex cell diversity in human disease is lacking …

Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in
response to cytokines. However, the cytokine responses in memory T cells remain largely …

Background COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from
asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are …

Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we
present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single …

Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

Temporal resolution of cellular features associated with a severe COVID-19 disease
trajectory is needed for understanding skewed immune responses and defining predictors of …

INTRODUCTION During tissue turnover, stem and progenitor cells differentiate to produce
mature cell types. To understand and ultimately control differentiation, it is important to …