Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

The Polycomb repressive system plays a fundamental role in controlling gene expression
during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 …

Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles
in stem-cell identity, differentiation and disease. Mechanistically, they function within …

Polycomb group proteins maintain the gene-expression pattern of different cells that is set
during early development by regulating chromatin structure. In mammals, two main …

Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …

More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Polycomb group proteins (PcGs) are essential epigenetic regulators that play key roles in
development, pluripotency, senescence, and cancer. Recent reports have found that the …

Polycomb group (PcG) proteins function as vital epigenetic regulators in various biological
processes, including pluripotency, development, and carcinogenesis. PcG proteins form …

The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …

Polycomb group (PcG) proteins are key regulators in establishing a transcriptional
repressive state. Polycomb Repressive Complex 2 (PRC2), one of the two major PcG protein …