Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we
profile the DNA methylome, transcriptome, and global occupancy of histone modifications …

Epigenetic mechanisms contribute to the establishment and maintenance of cell-type-
specific gene expression patterns. In this review, we focus on the functions of histone lysine …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

Histone modifications influence the interactions of transcriptional regulators with chromatin.
Studies in embryos and embryonic stem (ES) cells have uncovered histone modification …

Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

In mammals the genome is shaped by epigenetic regulation to manifest numerous cellular
identities. The term epigenetics has been used to refer to changes in gene expression …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …