OBJECTIVE Surgery for spinal deformity has the potential to improve pain, disability,
function, self-image, and mental health. These surgical procedures carry significant risk and …

OBJECTIVE Risk stratification is a critical element of surgical planning. Early tools were fairly
crude, while newer instruments incorporate disease-specific elements and markers of frailty …

Background DNA methylation-derived epigenetic clocks and frailty are well-established
biological age measures capturing different aging processes. However, whether they are …

Background Epigenetic clocks based on DNA methylation yield high correlations with
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …

Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …

Background The trajectory of frailty in older adults is important to public health; therefore,
markers that may help predict this and other important outcomes could be beneficial …

Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …

Background Biological ageing is one of the principal risk factors for neurodegenerative
diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …

Background: Epigenetic clocks estimate chronologic age using methylation levels at specific
loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal …