ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men

LE Martinez-Gomez, B Herrera-Lopez… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
current coronavirus disease 2019 (COVID-19) pandemic, affecting more than 219 countries …

ACE2 polymorphisms as potential players in COVID-19 outcome

AS Khayat, PP de Assumpção, BC Meireles Khayat… - PLoS …, 2020 - journals.plos.org
The clinical condition COVID-19, caused by SARS-CoV-2, was declared a pandemic by the
WHO in March 2020. Currently, there are more than 5 million cases worldwide, and the …

SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease

N Alimoradi, M Sharqi, D Firouzabadi, MM Sadeghi… - Virology Journal, 2022 - Springer
COVID-19 and the renin-angiotensin system (RAS) are linked by angiotensin-converting
enzyme 2 (ACE2), a key enzyme in RAS that has been validated as a SARS-CoV-2 receptor …

SARS-CoV-2 Susceptibility and ACE2 Gene Variations Within Diverse Ethnic Backgrounds

N Vadgama, A Kreymerman, J Campbell… - Frontiers in …, 2022 - frontiersin.org
There is considerable variability in the susceptibility and progression for COVID-19 and it
appears to be strongly correlated with age, gender, ethnicity and pre-existing health …

Association of ACE2 Gene Variants with the Severity of COVID-19 Disease—A Prospective Observational Study

J Sienko, I Marczak, M Kotowski, A Bogacz… - International Journal of …, 2022 - mdpi.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 virus
(SARS-CoV-2), has triggered an enormous scientific response. Many studies have focused …

SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype

N Yamamoto, Y Ariumi, N Nishida, R Yamamoto… - Gene, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). The relentless spread and pathogenicity of the virus have …

The impact of ACE2 polymorphisms on COVID-19 disease: susceptibility, severity, and therapy

F Chen, Y Zhang, X Li, W Li, X Liu… - Frontiers in Cellular and …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has currently spread worldwide, leading to high morbidity and …

[HTML][HTML] Role of genetic variants and gene expression in the susceptibility and severity of COVID-19

S Choudhary, K Sreenivasulu, P Mitra… - Annals of laboratory …, 2021 - synapse.koreamed.org
Since its first report in December 2019, coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly emerged as a …

Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients

A Novelli, M Biancolella, P Borgiani, D Cocciadiferro… - Human genomics, 2020 - Springer
Abstract Background Coronaviruses (CoV) are a large family of viruses that are common in
humans and many animal species. Animal coronaviruses rarely infect humans with the …

Susceptibilities of human ACE2 genetic variants in coronavirus infection

W Ren, Y Zhu, J Lan, H Chen, Y Wang, H Shi… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 235 million …