In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Our ability to study early human post-implantation development remains highly limited due
to the ethical and technical challenges associated with intrauterine development of the …

Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …

In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …

Our understanding of how human embryos develop before gastrulation, including spatial
self-organization and cell type ontogeny, remains limited by available two-dimensional …

Abstract Development of visceral organs such as the esophagus, lung, liver and stomach
are coordinated by reciprocal signaling interactions between the endoderm and adjacent …

The difficulty of studying post-implantation development in mammals has sparked a flurry of
activity to develop in vitro models, termed embryoids, based on self-organizing pluripotent …

3D gastruloids, aggregates of embryonic stem cells that recapitulate key aspects of gastrula-
stage embryos, have emerged as a powerful tool to study the early stages of mammalian …

Understanding the progression of early human embryonic development prior to implantation
is of fundamental biological importance. Greater insights into early developmental events …

Understanding human development is of fundamental biological and clinical importance.
Despite its significance, mechanisms behind human embryogenesis remain largely …