LINE‐1 hypomethylation is associated with radiation‐induced genomic instability in industrial radiographers

YH Cho, Y Jang, HD Woo, YJ Kim… - Environmental and …, 2019 - Wiley Online Library
Global DNA hypomethylation is proposed as a potential biomarker for cancer risk associated
with genomic instability, which is an important factor in radiation‐induced cancer. However …

Radiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers

Y Lee, YJ Kim, YJ Choi, JW Lee, S Lee… - … journal of radiation …, 2015 - Taylor & Francis
Purpose: We investigated the association between occupational radiation exposure and
DNA methylation changes in nuclear power plant workers. We also evaluated whether …

Identification of radiation-induced aberrant hypomethylation in colon cancer

JH Bae, JG Kim, K Heo, K Yang, TO Kim, JM Yi - BMC genomics, 2015 - Springer
Background Exposure to ionizing radiation (IR) results in the simultaneous activation or
downregulation of multiple signaling pathways that play critical roles in cell type-specific …

Radiation-induced epigenetic alterations after low and high LET irradiations

U Aypar, WF Morgan, JE Baulch - Mutation Research/Fundamental and …, 2011 - Elsevier
Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the
missing link in understanding radiation-induced genomic instability (RIGI). This study tests …

The relationship among occupational irradiation, DNA methylation status, and oxidative damage in interventional physicians

B Chen, Q Dai, Q Zhang, P Yan, A Wang, L Qu, Y Jin… - Medicine, 2019 - journals.lww.com
Ionizing radiation can induce deoxyribonucleic acid (DNA) methylation pattern change, and
ionizing radiation-induced oxidative damage may also affect DNA methylation status …

Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation

O Kovalchuk, P Burke, J Besplug, M Slovack… - Mutation Research …, 2004 - Elsevier
The biological and genetic effects of chronic low-dose radiation (LDR) exposure and its
relationship to carcinogenesis have received a lot of attention in the recent years. For …

Gamma irradiation does not induce detectable changes in DNA methylation directly following exposure of human cells

C Lahtz, SE Bates, Y Jiang, AX Li, X Wu, MA Hahn… - 2012 - journals.plos.org
Environmental chemicals and radiation have often been implicated in producing alterations
of the epigenome thus potentially contributing to cancer and other diseases. Ionizing …

The effect of radiation quality on genomic DNA methylation profiles in irradiated human cell lines

W Goetz, MNM Morgan, JE Baulch - Radiation research, 2011 - meridian.allenpress.com
It has been acknowledged for many years that radiation exposure induces delayed, non-
targeted effects in the progeny of the irradiated cell. Evidence is beginning to demonstrate …

Radiation-induced genomic instability: are epigenetic mechanisms the missing link?

U Aypar, WF Morgan, JE Baulch - International journal of radiation …, 2011 - Taylor & Francis
Purpose: This review examines the evidence for the hypothesis that epigenetics are
involved in the initiation and perpetuation of radiation-induced genomic instability (RIGI) …

Dose-dependence, sex-and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes

I Pogribny, J Raiche, M Slovack, O Kovalchuk - … and biophysical research …, 2004 - Elsevier
Radiation is a well-known genotoxic agent and human carcinogen that gives rise to a variety
of long-term effects. Its detrimental influence on cellular function is actively studied …