In mammals, recent studies have demonstrated that the brain, the hypothalamus in
particular, is a key bidirectional integrator of humoral and neural information from peripheral …

Brain aging is characterized by progressive loss of neurophysiological functions that is often
accompanied by age-associated neurodegeneration. Calorie restriction has been linked to …

The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein
deacylation is a unique feature of the family of proteins called 'sirtuins.'This intimate …

Members of the sirtuin family of protein deacetylases support and promote longevity in
diverse organisms and can extend life span when upregulated. Sirtuin pathways also …

The controversy around sirtuins and their functions in aging has drawn in the past few years
as much attention, if not more, from the scientific community and the public as they did when …

Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent
deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as …

Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of
NAD+-dependent enzymes that have been connected to a steadily growing set of biological …

Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent
enzymes that regulate a wide range of biological processes, including aging, in several …

Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast
longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are …

Most living organisms, including humans, age. Over time the ability to do physical and
intellectual work deteriorates, and susceptibility to infectious, metabolic, and …