The normative modeling framework for computational psychiatry

S Rutherford, SM Kia, T Wolfers, C Fraza, M Zabihi… - Nature protocols, 2022 - nature.com
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …

[HTML][HTML] Conceptualizing mental disorders as deviations from normative functioning

AF Marquand, SM Kia, M Zabihi, T Wolfers… - Molecular …, 2019 - nature.com
Normative models are a class of emerging statistical techniques useful for understanding the
heterogeneous biology underlying psychiatric disorders at the level of the individual …

Computational phenotyping in psychiatry: a worked example

P Schwartenbeck, K Friston - eneuro, 2016 - eneuro.org
Computational psychiatry is a rapidly emerging field that uses model-based quantities to
infer the behavioral and neuronal abnormalities that underlie psychopathology. If successful …

Model-based cognitive neuroscience approaches to computational psychiatry: clustering and classification

TV Wiecki, J Poland, MJ Frank - Clinical Psychological …, 2015 - journals.sagepub.com
Psychiatric research is in crisis. We highlight efforts to overcome current challenges by
focusing on the emerging field of computational psychiatry, which might enable the field to …

The two cultures of computational psychiatry

D Bennett, SM Silverstein, Y Niv - JAMA psychiatry, 2019 - jamanetwork.com
Computational psychiatryis a rapidly growing field that uses tools from cognitive science,
computational neuroscience, and machine learning to address difficult psychiatric questions …

[HTML][HTML] The promise of a model-based psychiatry: building computational models of mental ill health

TU Hauser, V Skvortsova, M De Choudhury… - The Lancet Digital …, 2022 - thelancet.com
Computational models have great potential to revolutionise psychiatry research and clinical
practice. These models are now used across multiple subfields, including computational …

Computational psychiatry as a bridge from neuroscience to clinical applications

QJM Huys, TV Maia, MJ Frank - Nature neuroscience, 2016 - nature.com
Translating advances in neuroscience into benefits for patients with mental illness presents
enormous challenges because it involves both the most complex organ, the brain, and its …

A roadmap for the development of applied computational psychiatry

MP Paulus, QJM Huys, TV Maia - Biological psychiatry: cognitive …, 2016 - Elsevier
Computational psychiatry (CP) is a burgeoning field that uses mathematical approaches to
investigate psychiatric disorders, derive quantitative predictions, and integrate data across …

Computational approaches to psychiatry

KE Stephan, C Mathys - Current opinion in neurobiology, 2014 - Elsevier
Highlights•We summarize recent progress in computational and physiological
models.•These advances provide a basis for future diagnostic applications in psychiatry.•A …

[HTML][HTML] Understanding heterogeneity in clinical cohorts using normative models: beyond case-control studies

AF Marquand, I Rezek, J Buitelaar, CF Beckmann - Biological psychiatry, 2016 - Elsevier
Background Despite many successes, the case-control approach is problematic in
biomedical science. It introduces an artificial symmetry whereby all clinical groups (eg …