Immunosenescence is the general term used to describe the aging-associated decline of
immunological function that explains the higher susceptibility to infectious diseases and …

Provided that one is aware of the limitations, studying cell aging outside the body using
culture techniques can yield important information which, however, always has to be …

Background During organismal aging, human T-cells shift towards less functional
phenotypes, often called senescent cells. As these cells have not been well characterized …

Human aging is associated with complex alterations that contribute to remodelling of
physiological processes and ultimately manifests in loss of tissue/organ function. Peripheral …

Background Aging is accompanied by alterations in immune response which leads to
increased susceptibility to infectious diseases, cancer, autoimmunity, and inflammatory …

With advancing age, many organs exhibit functional deterioration. The age‐associated
accumulation of senescent cells is believed to represent one factor contributing to this …

The study of T cell biology has been accelerated by substantial progress at the technological
level, particularly through the continuing advancement of flow cytometry. The conventional …

Age-related immunosenescence is characterized by progressive dysfunction of adaptive
immune response and increased autoimmunity. Nevertheless, the impact of aging on CD4+ …

Immunosenescence is a multi-faceted phenomenon at the root of age-associated immune
dysfunction. It can lead to an array of pathological conditions, including but not limited to a …

Aging leads to a progressive functional decline of the immune system, which renders the
elderly increasingly susceptible to disease and infection. The degree to which immune cell …