Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in
vitro,,,–, but their developmental potential is substantially extended by interactions with …

The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation 1 …

At the time of implantation in the maternal uterus, the mouse blastocyst possesses an inner
cell mass comprising two lineages: epiblast (Epi) and primitive endoderm (PrE) …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …

The application of human embryonic stem (ES) cells in medicine and biology has an
inherent reliance on understanding the starting cell population. Human ES cells differ from …

Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …

Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

INTRODUCTION Early mammalian development requires the formation of embryonic and
extraembryonic tissues and a highly coordinated partnership between them. This close …

Embryonic stem cells can be incorporated into the developing embryo and its germ line, but,
when cultured alone, their ability to generate embryonic structures is restricted. They can …