In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
I Maze, KM Noh, CD Allis - Neuropsychopharmacology, 2013 - nature.com
Postmitotic neurons are subject to a vast array of environmental influences that require the nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic …
Turnover and exchange of nucleosomal histones and their variants, a process long believed to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe a …
Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling, and histone post-translational modifications, are involved in multiple aspects of neuronal …
RD Salinas, DR Connolly… - … and applied neurobiology, 2020 - Wiley Online Library
Neural development requires the orchestration of dynamic changes in gene expression to regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …
J Sun, J Sun, G Ming, H Song - European Journal of …, 2011 - Wiley Online Library
Epigenetic regulation represents a fundamental mechanism to maintain cell‐type‐specific gene expression during development and serves as an essential mediator to interface the …
J Hsieh, FH Gage - Current opinion in cell biology, 2005 - Elsevier
Neural stem cells generate distinct cell types for tissue formation and cell replacement during development and throughout adulthood. Neural development and plasticity are …
J Feng, S Fouse, G Fan - Pediatric research, 2007 - nature.com
The development and function of the CNS requires accurate gene transcription control in response to proper environmental signals. Epigenetic mechanisms, including DNA …
Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic mechanism of gene expression regulation in various postmitotic neurons, both over time and …