Associations of the A/T/N profiles in PET, CSF, and plasma biomarkers with Alzheimer's disease neuropathology at autopsy

ZB Wang, L Tan, PY Gao, YH Ma, Y Fu… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION To examine the extent to which positron emission tomography (PET)‐,
cerebrospinal fluid (CSF)‐, and plasma‐related amyloid‐β/tau/neurodegeneration (A/T/N) …

Differences between ante mortem Alzheimer's disease biomarkers in predicting neuropathology at autopsy

ZB Wang, L Tan, HF Wang, SD Chen, Y Fu… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction This study aimed to assess whether biomarkers related to amyloid, tau, and
neurodegeneration can accurately predict Alzheimer's disease (AD) neuropathology at …

Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes

JM Long, DW Coble, C Xiong, SE Schindler, RJ Perrin… - Brain, 2022 - academic.oup.com
Alzheimer's disease biomarkers are widely accepted as surrogate markers of underlying
neuropathological changes. However, few studies have evaluated whether preclinical …

Characterization of Alzheimer's tau biomarker discordance using plasma, CSF, and PET

Y Guo, YY Huang, XN Shen, SD Chen, H Hu… - Alzheimer's research & …, 2021 - Springer
Background We aimed to investigate the tau biomarker discrepancies of Alzheimer's
disease (AD) using plasma tau phosphorylated at threonine 181 (p-tau181), cerebrospinal …

Mass spectrometry measures of plasma Aβ, tau and P‐tau isoforms' relationship to amyloid PET, tau PET, and clinical stage of Alzheimer's disease: Clinical study …

RJ Bateman, NR Barthelemy… - Alzheimer's & …, 2020 - Wiley Online Library
Background Recent advances in understanding the links between amyloid‐beta (Aβ) and
specific tau isoforms in brain, cerebrospinal fluid (CSF), and blood indicate that a cascade of …

P‐tau/aβ42 and aβ42/40 ratios in csf are equally predictive of amyloid pet status

MR Campbell, S Ashrafzadeh‐Kian… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Measurement of amyloid beta (Aβ40 and Aβ42) and tau (phosphorylated tau [p‐
tau] and total tau [t‐tau]) in cerebrospinal fluid (CSF) can be utilized to differentiate clinical …

Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease

VJ Lowe, ES Lundt, SM Albertson, SA Przybelski… - Alzheimer's & …, 2019 - Elsevier
Introduction Neuroimaging biomarkers are important for early diagnosis of Alzheimer's
disease, and comparing multimodality neuroimaging to autopsy data is essential. Methods …

Phospho‐tau217 and phospho‐tau181 in plasma and CSF as biomarkers for Alzheimer's disease: Clinical study results of AD blood biomarkers

S Janelidze, S Palmqvist, YT Quiroz… - Alzheimer's & …, 2020 - Wiley Online Library
Background Cerebrospinal fluid (CSF) p‐tau181 (tau phosphorylated at threonine 181) is an
established biomarker of Alzheimer's disease (AD) reflecting abnormal tau metabolism in …

Equivalence of plasma p‐tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease

J Therriault, S Servaes, C Tissot… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Plasma biomarkers are promising tools for Alzheimer's disease (AD)
diagnosis, but comparisons with more established biomarkers are needed. METHODS We …

Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease

S Janelidze, D Bali, NJ Ashton, NR Barthélemy… - Brain, 2023 - academic.oup.com
Plasma phospho-tau (p-tau) species have emerged as the most promising blood-based
biomarkers of Alzheimer's disease. Here, we performed a head-to-head comparison of p …