Sporadic Alzheimer's disease (AD) is a complex, multifactorial disease. We should therefore
expect to find many factors involved in its causation. The known neuropathology seen at …

Human studies are reviewed concerning whether “aging”-related mechanisms contribute to
Alzheimer's disease (AD) pathogenesis. AD is defined by specific neuropathology: neuritic …

Although Alzheimer's disease (AD) is the most common neurodegenerative disease, the
etiology of AD is not well understood. In some cases, genetic factors explain AD risk, but a …

The strategy for the development of new drugs for Alzheimer's disease (AD) recognizes that
an effective therapy requires early therapeutic intervention and a multifactorial approach that …

Alzheimer disease (AD) is a progressive and irreversible dementia syndrome characterized
by loss of intellectual capacity in many domains, altered behavior, inability to care for …

It is currently estimated that 50% of patients with Alzheimer disease (AD) suffer from
moderate to severe disease. 1 After diagnosis, the severity of AD can be staged by …

Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD)
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …

Abstract Alzheimer's disease (AD), the major cause of dementia among the elderly world-
wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority …

Peripheral insulin resistance is associated with hyperinsulinemia, which may be associated
with brain insulin deficiency that is characteristic of sporadic Alzheimer's disease (sAD) …

Neurons are postmitotic and do not divide once the brain has reached maturity. Although
neurons do have substantial ability to form new processes and terminals in response to …