The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …

Nowadays, it is well known that with advancing age individuals are at an increased
susceptibility to develop diseases such as Alzheimer's disease, infectious diseases, cancer …

Abstract On April 7, 8, 2009 a Symposium entitled" Pathophysiology of Successful and
Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn …

Aging of the immune system, or immunosenescence, is a complex subject best defined as a
decline in cell-mediated immunity, particularly with respect to T cell function. Paradoxically …

From a holistic point of view, aging results from the cumulative erosion of the various
systems. Among these, the immune system is interconnected to the rest as immune cells are …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most
striking consequences of immunosenescence, as it is believed to be linked to the majority of …

Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …