One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon
units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key …

The metabolome represents a complex network of biological events that reflects the
physiologic state of the organism in health and disease. Additionally, specific metabolites …

One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

Folate‐mediated one‐carbon metabolism (FOCM) comprises a network of interconnected
folate‐dependent metabolic pathways responsible for serine and glycine interconversion, de …

Significance: The mitochondrial energy-transducing capacity is essential for the
maintenance of neuronal function, and the impairment of energy metabolism and redox …

Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of
relevant pathways can extend life span. In this review, we will outline how cellular …

Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from
rare, inborn errors of metabolism to common, age-associated diseases such as …

Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and
cancer metabolism. Vital intermediary steps are localized to mitochondria, but it remains …

Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …

The impact of chronic caloric restriction (CR) on health and survival is complex with poorly
understood underlying molecular mechanisms. A recent study in mice addressing the diets …