A comprehensive AI‐driven analysis of large‐scale omic datasets reveals novel dual‐purpose targets for the treatment of cancer and aging

FW Pun, GHD Leung, HW Leung, J Rice… - Aging …, 2023 - Wiley Online Library
As aging and tumorigenesis are tightly interconnected biological processes, targeting their
common underlying driving pathways may induce dual‐purpose anti‐aging and anti‐cancer …

[HTML][HTML] Single-cell transcriptomics reveals the expression of aging-and senescence-associated genes in distinct cancer cell populations

D Saul, RL Kosinsky - Cells, 2021 - mdpi.com
The human aging process is associated with molecular changes and cellular degeneration,
resulting in a significant increase in cancer incidence with age. Despite their potential …

[HTML][HTML] Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

FW Pun, GHD Leung, HW Leung, BHM Liu… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Aging biology is a promising and burgeoning research area that can yield dual-purpose
pathways and protein targets that may impact multiple diseases, while retarding or possibly …

Comprehensive transcriptome profiling in elderly cancer patients reveals aging‐altered immune cells and immune checkpoints

Y Wu, J Wei, X Chen, Y Qin, R Mao… - … Journal of Cancer, 2019 - Wiley Online Library
Aging is the single most significant risk factor for cancer development. However, the
potential impact of aging on cancer microenvironment remains poorly understood. Here, we …

[HTML][HTML] Integrated multi-omics for novel aging biomarkers and antiaging targets

L Wu, X Xie, T Liang, J Ma, L Yang, J Yang, L Li, Y Xi… - Biomolecules, 2021 - mdpi.com
Aging is closely related to the occurrence of human diseases; however, its exact biological
mechanism is unclear. Advancements in high-throughput technology provide new …

AgeAnno: a knowledgebase of single-cell annotation of aging in human

K Huang, H Gong, J Guan, L Zhang, C Hu… - Nucleic Acids …, 2023 - academic.oup.com
Aging is a complex process that accompanied by molecular and cellular alterations. The
identification of tissue-/cell type-specific biomarkers of aging and elucidation of the detailed …

Aging Atlas: a multi-omics database for aging biology

Nucleic acids research, 2021 - academic.oup.com
Organismal aging is driven by interconnected molecular changes encompassing internal
and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets …

[PDF][PDF] Pan-cancer analysis reveals molecular patterns associated with age

Y Shah, A Verma, AR Marderstein, J White, B Bhinder… - Cell reports, 2021 - cell.com
Older age is a strong risk factor for several diseases, including cancer. The etiology and
biology of age-associated differences among cancers are poorly understood. To address …

AgingBank: a manually curated knowledgebase and high-throughput analysis platform that provides experimentally supported multi-omics data relevant to aging in …

Y Gao, S Shang, S Guo, X Wang, H Zhou… - Briefings in …, 2022 - academic.oup.com
Discovering the biological basis of aging is one of the greatest remaining challenges for
biomedical field. Work on the biology of aging has discovered a range of interventions and …

[HTML][HTML] Age-associated differences in the cancer molecular landscape

K Chatsirisupachai, C Lagger, JP de Magalhães - Trends in cancer, 2022 - cell.com
Cancer is an age-related disease, as incidence and mortality for most types of cancer
increase with age. However, how molecular alterations in tumors differ among patients of …