The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

The skin epidermis is constantly renewed throughout life,. Disruption of the balance between
renewal and differentiation can lead to uncontrolled growth and tumour initiation. However …

Fingerprints are complex and individually unique patterns in the skin. Established prenatally,
the molecular and cellular mechanisms that guide fingerprint ridge formation and their …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

During development, progenitors simultaneously activate one lineage while silencing
another, a feature highly regulated in adult stem cells but derailed in cancers. Equipped to …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …