Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Whether and how certain transposable elements with viral origins, such as endogenous
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …

Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …

Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …

Most age-related neurodegenerative diseases remain incurable owing to an incomplete
understanding of the disease mechanisms. Several environmental and genetic factors …

So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

This review explores the emerging role of hydrogen sulfide (H2S) in modulating epigenetic
mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to …