CpG islands near promoters are normally unmethylated despite being surrounded by
densely methylated regions. Aberrant hypermethylation of these CpG islands has been …

Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the
aging population, and often leads to joint pain, disability, and a diminished quality of life …

Kabuki syndrome is a recognizable Mendelian disorder characterized by the clinical
constellation of childhood hypotonia, developmental delay or intellectual impairment, and …

Background The causal relationship and the direction of the effect between depression and
aging remain controversial. Methods We used a bidirectional two-sample Mendelian …

Cancer is a global epidemic that has affected millions of lives. Discovering novel cancer
targets is widely viewed as a key step in developing more effective therapies for cancer and …

Recent scientific interest has been directed towards age-related diseases, driven by the
significant increase in global life expectancy and the growing population of individuals aged …

Biological clock technologies are designed to assess the acceleration of biological age (B-
age) in diverse cell types, offering a distinctive opportunity in toxicogenomic research to …

The trajectory of human aging varies widely from one individual to the next due to complex
interactions between the genome and the environment that influence the aging process …

The physiological quantum of stress-inducible transcriptional protein, Lens Epithelium-
Derived Growth Factor (LEDGF), is vital for the maintenance of cellular physiology. Erratic …

The liver is the primary organ accountable for complex physiological functions, including
lipid metabolism, toxic chemical degradation, bile acid synthesis, and glucose metabolism …