Aging represents a key risk factor for a plethora of diseases. Targeting detrimental
processes which occur during aging, especially before onset of age-related disease, could …

Age-associated changes in DNA methylation have been characterized across various
animals, but not yet in amphibians, which are of particular interest because they include …

Liver, an important regulator of metabolic homeostasis, is critical for healthy brain function. In
particular, age‐related neurodegenerative diseases seriously reduce the quality of life for …

Abstract N 6-methyladenosine (m 6 A), the most prevalent mRNA modification in eukaryotic
cells, is known to play regulatory roles in a wide array of biological processes, including …

The process of aging inevitably leads to an increase in age-related comorbidities, including
chronic kidney disease (CKD). In many aspects, CKD can be considered a state of …

Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell
damage. Continual functional decline in the intrinsic ability of living organisms to accurately …

Significant developments in cancer treatment have been made since the advent of immune
therapies. However, there are still some patients with malignant tumors who do not benefit …

Abstract BRG1 (Brahma-related gene 1) is a member of the SWI/SNF (switch/sucrose
nonfermentable) chromatin remodeling complex which utilizes the energy from ATP …

Aging is defined as a progressive decline of cognitive and physiological functions over
lifetime. Since the definition of the nine hallmarks of aging in 2013 by López-Otin, numerous …

Long noncoding RNAs (lncRNAs) have emerged as major regulators of gene expression,
chromatin structure, epigenetic changes, post-transcriptional processing of RNAs …