Rutin: A flavonoid as an effective sensitizer for anticancer therapy; insights into multifaceted mechanisms and applicability for combination therapy

A Satari, S Ghasemi, S Habtemariam… - Evidence‐Based …, 2021 - Wiley Online Library
Rutin is a unique antioxidant flavonoid that is mainly found in fruit, vegetables, cereals, and
many other plant‐based human diets. This review aims to highlight the in vitro anticancer …

Rutin as a potent antioxidant: Implications for neurodegenerative disorders

AB Enogieru, W Haylett, DC Hiss… - Oxidative medicine …, 2018 - Wiley Online Library
A wide range of neurodegenerative diseases (NDs), including Alzheimer's disease,
Parkinson's disease, Huntington's disease, and prion diseases, share common mechanisms …

Molecular mechanisms of anticancer effect of rutin

A Imani, N Maleki, S Bohlouli… - Phytotherapy …, 2021 - Wiley Online Library
Because of the extensive biological functions of natural substances such as bioflavonoids,
and their high safety and low costs, they could have high priority application in the health …

The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

AK Farha, RY Gan, HB Li, DT Wu… - Critical Reviews in …, 2022 - Taylor & Francis
Rutin is one of the most common dietary polyphenols found in vegetables, fruits, and other
plants. It is metabolized by the mammalian gut microbiota and absorbed from the intestines …

[HTML][HTML] Advances in applying computer-aided drug design for neurodegenerative diseases

MM Salman, Z Al-Obaidi, P Kitchen, A Loreto… - International journal of …, 2021 - mdpi.com
Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …

[HTML][HTML] Doxorubicin-induced cognitive impairment: the mechanistic insights

J Du, A Zhang, J Li, X Liu, S Wu, B Wang… - Frontiers in …, 2021 - frontiersin.org
Chemotherapy can significantly prolong the survival of patients with breast cancer;
Nevertheless, the majority of patients receiving chemotherapy such as doxorubicin may …

Doxorubicin and cisplatin induced cognitive impairment: the possible mechanisms and interventions

B Ongnok, N Chattipakorn, SC Chattipakorn - Experimental neurology, 2020 - Elsevier
Chemotherapy has significantly increased the number of cancer survivors. However,
chemotherapy itself carries various adverse effects that limit the efficacy of treatment and …

[HTML][HTML] Animal models of chemotherapy-induced cognitive decline in preclinical drug development

J John, M Kinra, J Mudgal, GL Viswanatha… - …, 2021 - Springer
Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …

[HTML][HTML] Neuroimmunology of behavioral comorbidities associated with cancer and cancer treatments

JC Santos, LM Pyter - Frontiers in immunology, 2018 - frontiersin.org
Behavioral comorbidities (depression, anxiety, fatigue, cognitive disturbances, and
neuropathic pain) are prevalent in cancer patients and survivors. These mental and …

Rutin as neuroprotective agent: From bench to bedside

B Budzynska, C Faggio, M Kruk-Slomka… - Current medicinal …, 2019 - ingentaconnect.com
Flavonoids are major dietary constituents of plant-based food found ubiquitously in plant
kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type …