Transposable elements (TEs) are mobile DNA sequences that colonize genomes and
threaten genome integrity. As a result, several mechanisms appear to have emerged during …

Highlights•Long read sequencing has improved genome assembly by an order of
magnitude.•New genome assembly algorithms leverage long, error prone reads to untangle …

INTRODUCTION Axolotls (Ambystoma mexicanum) and other salamanders are the only
tetrapods that can regenerate whole limbs. During this complex process, changes in gene …

An outstanding mystery in biology is why some species, such as the axolotl, can regenerate
tissues whereas mammals cannot. Here, we demonstrate that rapid activation of protein …

Lungfishes belong to lobe-fined fish (Sarcopterygii) that, in the Devonian
period,'conquered'the land and ultimately gave rise to all land vertebrates, including …

Background The ability to generate long sequencing reads and access long-range linkage
information is revolutionizing the quality and completeness of genome assemblies. Here we …

Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated
effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema …

Vertebrates harbor recognizably orthologous gene complements but vary 100-fold in
genome size. How chromosomal organization scales with genome expansion is unclear …

Genomic sequencing technologies have revolutionized mutation detection of the genetic
diseases in the past few years. In recent years, the third generation sequencing (TGS) has …

Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …