Automated assembly of centromeres from ultra-long error-prone reads

AV Bzikadze, PA Pevzner - Nature Biotechnology, 2020 - nature.com
Centromeric variation has been linked to cancer and infertility, but centromere sequences
contain multiple tandem repeats and can only be assembled manually from long error-prone …

[HTML][HTML] Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration

Y Shao, XB Wang, JJ Zhang, ML Li, SS Wu… - Nature …, 2020 - nature.com
The earthworm is particularly fascinating to biologists because of its strong regenerative
capacity. However, many aspects of its regeneration in nature remain elusive. Here we …

State of the Amphibia 2020: A review of five years of amphibian research and existing resources

MC Womack, E Steigerwald… - Ichthyology & …, 2022 - meridian.allenpress.com
Amphibians are a clade of over 8,400 species that provide unique research opportunities
and challenges. With amphibians undergoing severe global declines, we posit that …

Advancements to the axolotl model for regeneration and aging

WA Vieira, KM Wells, CD McCusker - Gerontology, 2020 - karger.com
Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …

Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution

F Ye, G Zhang, WE, H Chen, C Yu, L Yang… - Nature …, 2022 - nature.com
Abstract The Mexican axolotl (Ambystoma mexicanum) is a well-established tetrapod model
for regeneration and developmental studies. Remarkably, neotenic axolotls may undergo …

Repeat-sequence turnover shifts fundamentally in species with large genomes

P Novák, MS Guignard, P Neumann, LJ Kelly… - Nature Plants, 2020 - nature.com
Abstract Given the 2,400-fold range of genome sizes (0.06–148.9 Gbp (gigabase pair)) of
seed plants (angiosperms and gymnosperms) with a broadly similar gene content …

Walking with salamanders: from molecules to biorobotics

D Ryczko, A Simon, AJ Ijspeert - Trends in neurosciences, 2020 - cell.com
How do four-legged animals adapt their locomotion to the environment? How do central and
peripheral mechanisms interact within the spinal cord to produce adaptive locomotion and …

Time to go: neural crest cell epithelial-to-mesenchymal transition

TA Leathers, CD Rogers - Development, 2022 - journals.biologists.com
Neural crest cells (NCCs) are a dynamic, multipotent, vertebrate-specific population of
embryonic stem cells. These ectodermally-derived cells contribute to diverse tissue types in …

Aquatic insects are dramatically underrepresented in genomic research

S Hotaling, JL Kelley, PB Frandsen - Insects, 2020 - mdpi.com
Simple Summary The genome is the basic evolutionary unit underpinning life on Earth.
Knowing its sequence, including the many thousands of genes coding for proteins in an …

A large genome with chromosome‐scale assembly sheds light on the evolutionary success of a true toad (Bufo gargarizans)

B Lu, J Jiang, H Wu, X Chen, X Song… - Molecular Ecology …, 2021 - Wiley Online Library
We present a high‐quality genome assembly for the Asiatic toad (Bufo gargarizans) and
explore the evolution of several large gene families in amphibians. With a large genome …