Roles of transposable elements in the regulation of mammalian transcription
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …
contain sequences capable of recruiting the host transcription machinery, which they use to …
Transposable elements shape the evolution of mammalian development
AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements
M Burbage, A Rocañín-Arjó, B Baudon, YA Arribas… - Science …, 2023 - science.org
Oncogenesis often implicates epigenetic alterations, including derepression of transposable
elements (TEs) and defects in alternative splicing. Here, we explore the possibility that …
elements (TEs) and defects in alternative splicing. Here, we explore the possibility that …
[HTML][HTML] Taming transposable elements in vertebrates: from epigenetic silencing to domestication
Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …
known to date. Because their expression and mobility can lead to genomic instability …
Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis
Retrotransposons are highly enriched in the animal genome,–. The activation of
retrotransposons can rewrite host DNA information and fundamentally impact host biology …
retrotransposons can rewrite host DNA information and fundamentally impact host biology …
Analyses of 600+ insect genomes reveal repetitive element dynamics and highlight biodiversity-scale repeat annotation challenges
Repetitive elements (REs) are integral to the composition, structure, and function of
eukaryotic genomes, yet remain understudied in most taxonomic groups. We investigated …
eukaryotic genomes, yet remain understudied in most taxonomic groups. We investigated …
[HTML][HTML] A beginner's guide to manual curation of transposable elements
Background In the study of transposable elements (TEs), the generation of a high
confidence set of consensus sequences that represent the diversity of TEs found in a given …
confidence set of consensus sequences that represent the diversity of TEs found in a given …
Earl Grey: a fully automated user-friendly transposable element annotation and analysis pipeline
Transposable elements (TEs) are major components of eukaryotic genomes and are
implicated in a range of evolutionary processes. Yet, TE annotation and characterization …
implicated in a range of evolutionary processes. Yet, TE annotation and characterization …
[HTML][HTML] Transposable elements as essential elements in the control of gene expression
A Gebrie - Mobile DNA, 2023 - Springer
Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …