Parkinson's disease: convergence on synaptic homeostasis

SF Soukup, R Vanhauwaert, P Verstreken - The EMBO journal, 2018 - embopress.org
Parkinson's disease, the second most common neurodegenerative disorder, affects millions
of people globally. There is no cure, and its prevalence will double by 2030. In recent years …

[HTML][HTML] Effect of Parkinson's disease and related medications on the composition of the fecal bacterial microbiota

S Weis, A Schwiertz, MM Unger, A Becker… - npj Parkinson's …, 2019 - nature.com
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. PD
patients suffer from gastrointestinal dysfunctions and alterations of the autonomous nervous …

[HTML][HTML] The search for environmental causes of Parkinson's disease: Moving forward

H Chen, B Ritz - Journal of Parkinson's disease, 2018 - content.iospress.com
It is widely believed that environmental exposures contribute to the vast majority of late-
onset sporadic Parkinson's disease (PD), alone or via interactions with genetic factors. The …

[HTML][HTML] Prevalence of prodromal symptoms of Parkinson's disease in the late middle-aged population

DS Roos, M Klein, DJH Deeg, RL Doty… - Journal of …, 2022 - content.iospress.com
Background: The prodromal phase of Parkinson's disease (PD) can last up to 20 years and
is characterized by a variety of non-motor symptoms. Objective: To determine the prevalence …

[HTML][HTML] Parkinson's disease and gut microbiota: from clinical to mechanistic and therapeutic studies

X Zhang, B Tang, J Guo - Translational Neurodegeneration, 2023 - Springer
Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. The
typical symptomatology of PD includes motor symptoms; however, a range of nonmotor …

[HTML][HTML] The role of the gut microbiota in the pathogenesis of Parkinson's disease

D Yang, D Zhao, SZ Ali Shah, W Wu, M Lai… - Frontiers in …, 2019 - frontiersin.org
It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and
energy cycles. The GM also has effects on neurological outcomes via many mechanisms …

Constipation in Parkinson's disease: a systematic review and meta-analysis

L Yao, W Liang, J Chen, Q Wang, X Huang - European Neurology, 2023 - karger.com
Introduction: Constipation is a common nonmotor symptom of Parkinson's disease (PD) and
has been reported to increase the risk of developing PD. However, previous studies have …

Sleep and risk of parkinsonism and Parkinson's disease: a population-based study

TS Lysen, SKL Darweesh, MK Ikram, AI Luik, MA Ikram - Brain, 2019 - academic.oup.com
Sleep disturbances may signal presence of prodromal parkinsonism, including Parkinson's
disease. Whether general sleep quality or duration in otherwise healthy subjects is related to …

[HTML][HTML] A scoping review of neurodegenerative manifestations in explainable digital phenotyping

H Alfalahi, SB Dias, AH Khandoker… - npj Parkinson's …, 2023 - nature.com
Neurologists nowadays no longer view neurodegenerative diseases, like Parkinson's and
Alzheimer's disease, as single entities, but rather as a spectrum of multifaceted symptoms …

Parkinson's disease: from bench to bedside

A Draoui, O El Hiba, A Aimrane, A El Khiat… - Revue …, 2020 - Elsevier
Parkinson's disease is a very complex public health problem with different etiologies and a
wide range of clinical features including motor and non-motor symptoms. The aim of the …