Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Imbalance in the tissue microenvironment is the main obstacle to drug delivery and
distribution in the human body. Before penetrating the pathological tissue microenvironment …

Developing a drug delivery platform that possesses universal drug loading capacity to meet
various requirements of cancer treatment is a challenging yet interesting task. Herein, a self …

Tumor extracellular matrix (ECM) not only forms a physical barrier for T cells infiltration, but
also regulates multiple immunosuppressive pathways, which is an important reason for …

恶性肿瘤对人类生命健康构成了巨大威胁. 在全球范围内, 恶性肿瘤已经成为世界人口的主要
死因之一, 据世界卫生组织统计, 2020 年全球近1/6 的死亡是由恶性肿瘤导致的 …

Multiple myeloma (MM) is a distinguished hematologic malignancy, with existing studies
elucidating its interaction with neutrophil extracellular traps (NETs), which may potentially …

Mechanical features of cancer cells emerge as a distinct trait during development and
progression of solid tumors. Herein, we discuss recent key findings regarding the impact of …

Chemotherapy based on small molecule drugs, hormones, cycline kinase inhibitors, and
monoclonal antibodies has been widely used for breast cancer treatment in the clinic but …