The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells, including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …
The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli into the coordinated regulation of intracellular signals, cellular function, gene expression …
S Phuyal, P Romani, S Dupont, H Farhan - Trends in Cell Biology, 2023 - cell.com
Mechanobiology studies the mechanisms by which cells sense and respond to physical forces, and the role of these forces in shaping cells and tissues themselves …
Y Mao, SA Wickström - Nature Reviews Molecular Cell Biology, 2024 - nature.com
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues undergo constant changes in genome activity, cell fate …
The ability to maintain and differentiate cells in vitro is critical to many advances in the field of bioengineering. However, on traditional, stiff (E≈ GPa) culture substrates, cells are …
E Felli, S Selicean, S Guixé-Muntet, C Wang, J Bosch… - JHEP reports, 2023 - Elsevier
The interplay between mechanical stimuli and cellular mechanobiology orchestrates the physiology of tissues and organs in a dynamic balance characterized by constant …
All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …
M Guo, F Yang, L Zhu, L Wang, Z Li, Z Qi… - Nature …, 2024 - nature.com
Natural evolution has resulted in reduced cold tolerance in cultivated tomato (Solanum lycopersicum). Herein, we perform a combined analysis of ATAC-Seq and RNA-Seq in cold …
C Villeneuve, A Hashmi, I Ylivinkka… - Nature Cell …, 2024 - nature.com
Morphogenesis and cell state transitions must be coordinated in time and space to produce a functional tissue. An excellent paradigm to understand the coupling of these processes is …