The use of repurposing drugs that may have neoplastic and anticancer effects increases the
efficiency and decrease resistance to chemotherapy drugs through a biochemical and …

The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular
matrix (ECM) is an important TME component. Collagen is a major ECM component that …

Cisplatin is a well-known platinum-based chemotherapy medication that is widely utilized for
some malignancies. Despite the direct cytotoxic consequences of cisplatin on tumor cells …

The survival of non-small cell lung cancer (NSCLC) patients has improved in the last decade
as a result of introducing new therapeutics, such as immune checkpoint inhibitors, in the …

Simple Summary Pancreatic cancer is difficult to treat. Novel treatment strategies are
urgently needed to improve the survival rate, which is approximately 10% five years after …

Simple Summary As a solid tumor, melanoma is not only a tumor mass of monolithic tumor
cells, but it also contains supporting stroma, extracellular matrix (ECM), and soluble …

Solid tumors are composed of a highly complex and heterogenic microenvironment, with
increasing metabolic status. This environment plays a crucial role in the clinical therapeutic …

Biomechanical forces are of fundamental importance in biology, diseases, and medicine.
Mechanobiology is an emerging interdisciplinary field that studies how biological …

Currently, the most commonly used treatments for cancer are surgery, radiotherapy, and
chemotherapy [1–6]. All three methods could lead to damaging normal tissues or the …

The evaluation of nanostructured biomaterials and medicines is associated with 2D cultures
that provide insight into biological mechanisms at the molecular level, while critical aspects …