FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms

SK Azzam, H Alsafar, AA Sajini - International journal of molecular …, 2022 - mdpi.com
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …

Modelling metabolic diseases and drug response using stem cells and organoids

W Hu, MA Lazar - Nature Reviews Endocrinology, 2022 - nature.com
Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

Organoids: The current status and biomedical applications

S Yang, H Hu, H Kung, R Zou, Y Dai, Y Hu… - MedComm, 2023 - Wiley Online Library
Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Regulatory mechanisms of the early phase of white adipocyte differentiation: An overview

M Audano, S Pedretti, D Caruso, M Crestani… - Cellular and molecular …, 2022 - Springer
The adipose organ comprises two main fat depots termed white and brown adipose tissues.
Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor …

The use of stem cell-derived organoids in disease modeling: an update

J Azar, HF Bahmad, D Daher, MM Moubarak… - International Journal of …, 2021 - mdpi.com
Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

[HTML][HTML] Translational products of adipose tissue-derived mesenchymal stem cells: Bench to bedside applications

S Sharma, S Muthu, M Jeyaraman… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
With developments in the field of tissue engineering and regenerative medicine, the use of
biological products for the treatment of various disorders has come into the limelight among …

Optical diffraction tomography and Raman spectroscopy reveal distinct cellular phenotypes during white and brown adipocyte differentiation

P Anantha, Z Liu, P Raj, I Barman - Biosensors and Bioelectronics, 2023 - Elsevier
White adipose tissue (WAT) and brown adipose tissue (BAT) are the primary types of fats in
humans, and they play prominent roles in energy storage and thermogenesis, respectively …

Secreted frizzled related proteins in cardiovascular and metabolic diseases

H Guan, J Zhang, J Luan, H Xu, Z Huang… - Frontiers in …, 2021 - frontiersin.org
Abnormal gene expression and secreted protein levels are accompanied by extensive
pathological changes. Secreted frizzled related protein (SFRP) family members are …

Autologous human immunocompetent white adipose tissue‐on‐chip

J Rogal, J Roosz, C Teufel, M Cipriano, R Xu… - Advanced …, 2022 - Wiley Online Library
Obesity and associated diseases, such as diabetes, have reached epidemic proportions
globally. In this era of “diabesity”, white adipose tissue (WAT) has become a target of high …

The inflammatory profile of obesity and the role on pulmonary bacterial and viral infections

F Hornung, J Rogal, P Loskill, B Löffler… - International journal of …, 2021 - mdpi.com
Obesity is a globally increasing health problem, entailing diverse comorbidities such as
infectious diseases. An obese weight status has marked effects on lung function that can be …