Immune checkpoint inhibitors in cancer therapy
The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …
Targeting the tumor stroma for cancer therapy
M Xu, T Zhang, R Xia, Y Wei, X Wei - Molecular Cancer, 2022 - Springer
Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix
The efficacy of adoptive T-cell therapies largely depends on the generation of T-cell
populations that provide rapid effector function and long-term protective immunity. Yet it is …
populations that provide rapid effector function and long-term protective immunity. Yet it is …
Tumor microenvironment signaling and therapeutics in cancer progression
Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy
Y Ding, Y Wang, Q Hu - Exploration, 2022 - Wiley Online Library
Immunotherapy strategies that use cell‐based delivery systems have sparked much interest
in the treatment of malignancies, owing to their high biocompatibility, excellent tumor …
in the treatment of malignancies, owing to their high biocompatibility, excellent tumor …
Extracellular‐vesicle‐based drug delivery systems for enhanced antitumor therapies through modulating the cancer‐immunity cycle
T Yong, Z Wei, L Gan, X Yang - Advanced Materials, 2022 - Wiley Online Library
Although immunotherapy harnessing activity of the immune system against tumors has
made great progress, the treatment efficacy remains limited in most cancers. Current …
made great progress, the treatment efficacy remains limited in most cancers. Current …
Extracellular vesicles: new classification and tumor immunosuppression
Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …
Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies
Cells have emerged as a promising new form of drug delivery carriers owing to their
distinguished advantages such as naturally bypassing immune recognition, intrinsic …
distinguished advantages such as naturally bypassing immune recognition, intrinsic …
Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk
Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …