Loss of normal tissue architecture is a hallmark of oncogenic transformation. In developing
organisms, tissues architectures are sculpted by mechanical forces during morphogenesis …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Nanomedicine has been developed for cancer therapy over several decades, while rapid
clearance from blood circulation by reticuloendothelial system (RES) severely limits …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Immunotherapy based on immune checkpoint inhibitors has evolved into a new pillar of
cancer treatment in clinics, but dealing with treatment resistance (either primary or acquired) …

Engineered nanomaterials have been extensively employed as therapeutics for tumor
management. Meanwhile, the complex tumor niche along with multiple barriers at the …

In many cancers, tumour progression is associated with increased tissue stiffness. Yet, the
mechanisms associating tissue stiffness with tumorigenesis and malignant transformation …

The leukocyte Fcγ receptor (FcγR)-mediated response is important for the efficacy of
therapeutic antibodies; however, little is known about the role of FcγRs in other cell types …

The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …