Mechanotransduction, the translation of mechanical stimuli into biological signals, is a
crucial mechanism involved in the function of fundamentally all cell types. In many solid …

Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …

Background: Tumorigenesis is attributed to the interactions of cancer cells with the tumor
microenvironment through both biochemical cues and physical stimuli. Increased matrix …

In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

The most abundant cell type in the tumor microenvironment are cancer-associated
fibroblasts (CAFs). CAFs play an important role in tumor growth and progression. Besides …

Background Cancer-associated fibroblasts (CAFs) are a vital constituent of the tumor
microenvironment (TME) and have several activities, but the effect of CAF heterogeneity on …

In the colon, long-term exposure to chronic inflammation drives colitis-associated colon
cancer (CAC) in patients with inflammatory bowel disease. While the causal and clinical …

Cancer kills millions of individuals every year all over the world (Global Cancer
Observatory). The physiological and biomechanical processes underlying the tumor are still …

Cancer stem-like cells (CSCs) depend highly on hypoxia in solid tumors and represent an
intractable challenge for marketed nanomedicines. Herein, we for the first time leveraged …

Nanoparticles (NPs)‐based cancer therapeutics are generally impeded by poor drug
penetration into solid tumors due to their dense tumor extracellular matrix (ECM). Herein …