The tumor microenvironment (TME) plays decisive roles in disabling T cell-mediated
antitumor immunity, but the immunoregulatory functions of its biophysical properties remain …

Alterations in extracellular matrix (ECM) architecture and stiffness represent hallmarks of
cancer. Whether the biomechanical property of ECM impacts the functionality of tumor …

The function of biological tissues in health and disease is regulated at cellular level and is
highly influenced by the physical microenvironment, through the interaction of forces …

Metastasis remains the leading cause of cancer lethality. The'seed/soil'hypothesis provides
the framework to explain this cancer phenomenon where the concept of organotropism has …

Increased tissue stiffness is a hallmark of cancer and promotes tumor progression. It is
hypothesized that decreased tumorous stress may aid or sensitize chemotherapies. To …

Integrin-mediated adhesion of cells to the extracellular matrix (ECM) is crucial for the
physiological development and functioning of tissues but is pathologically disrupted in …

Over the past decade, immunotherapy has emerged as one of the most promising
approaches to cancer treatment. The use of immune checkpoint inhibitors has resulted in …

Malignant tumor tissues exhibit inter-and intratumoral heterogeneities, aberrant
development, dynamic stromal composition, diverse tissue phenotypes, and cell populations …

Living tissues embody a unique class of hybrid materials in which active and thermal forces
are inextricably linked. Mechanical characterization of tissues demands descriptors that …

Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and
infected cells, which makes them unique 'off-the-shelf'candidates for a new generation of …