Effect of biophysical properties of tumor extracellular matrix on intratumoral fate of nanoparticles: Implications on the design of nanomedicine

Y Tian, T Cheng, F Sun, Y Zhou, C Yuan, Z Guo… - Advances in Colloid and …, 2024 - Elsevier
Nanomedicine has a profound impact on various research domains including drug delivery,
diagnostics, theranostics, and regenerative medicine. Nevertheless, the clinical translation …

Correlation between the Warburg effect and progression of triple-negative breast cancer

S Liu, Y Li, M Yuan, Q Song, M Liu - Frontiers in Oncology, 2023 - frontiersin.org
Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted
therapy due to the negative expression of the estrogen receptor, progesterone receptor, and …

Bulk rheometry at high frequencies: a review of experimental approaches

B Schroyen, D Vlassopoulos, P Van Puyvelde… - Rheologica Acta, 2020 - Springer
High-frequency rheology is a form of mechanical spectroscopy which provides access to fast
dynamics in soft materials and hence can give valuable information about the local scale …

[HTML][HTML] Bioprinting and its use in tumor-on-a-chip technology for cancer drug screening: A review

L Fang, Y Liu, J Qiu, W Wan - International journal of bioprinting, 2022 - ncbi.nlm.nih.gov
The rising global incidence of cancer and high attrition rates of anticancer drugs make it
imperative to design novel screening platforms to increase the success rate of …

Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin

SP Pothapragada, P Gupta, S Mukherjee… - Nature communications, 2022 - nature.com
In epithelia, normal cells recognize and extrude out newly emerged transformed cells by
competition. This process is the most fundamental epithelial defence against cancer, whose …

Extracellular vesicles: an emerging mechanism governing the secretion and biological roles of tenascin-C

L Albacete-Albacete, M Sánchez-Álvarez… - Frontiers in …, 2021 - frontiersin.org
ECM composition and architecture are tightly regulated for tissue homeostasis. Different
disorders have been associated to alterations in the levels of proteins such as collagens …

Mechanical properties in the glioma microenvironment: emerging insights and theranostic opportunities

AG Bhargav, JS Domino, R Chamoun… - Frontiers in …, 2022 - frontiersin.org
Gliomas represent the most common malignant primary brain tumors, and a high-grade
subset of these tumors including glioblastoma are particularly refractory to current standard …

The biological and biomechanical role of transglutaminase-2 in the tumour microenvironment

R Tempest, S Guarnerio, R Maani, J Cooper, N Peake - Cancers, 2021 - mdpi.com
Simple Summary Transglutaminase-2 (TG2) is an enzyme primarily involved in protein cross-
linking, which has been shown to play a role in the development and progression of …

The role of mechanosensitive ion channels in the gastrointestinal tract

H Yang, C Hou, W Xiao, Y Qiu - Frontiers in Physiology, 2022 - frontiersin.org
Mechanosensation is essential for normal gastrointestinal (GI) function, and abnormalities in
mechanosensation are associated with GI disorders. There are several mechanosensitive …

Engineering heterogeneous tumor models for biomedical applications

Z Wu, D Huang, J Wang, Y Zhao, W Sun… - Advanced …, 2024 - Wiley Online Library
Tumor tissue engineering holds great promise for replicating the physiological and
behavioral characteristics of tumors in vitro. Advances in this field have led to new …