Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …

Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

Abstract Annually, there are 1.6 million new cases of cancer and nearly 600,000 cancer
deaths in the United States alone. The public health burden associated with these numbers …

Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene
regulation and encompass the well-known microRNAs (miRNAs), as well as the most …

In most tissues, anchorage-dependent growth and cell cycle progression are dependent on
cells engaging extracellular matrices (ECMs) via integrin–receptor adhesion complexes. In a …

Several evidences support the concept that cancer development and progression are not
entirely cancer cell-autonomous processes, but may be influenced, and possibly driven, by …

Breast cancer is a complex and heterogeneous disease: Several molecular alterations
cause cell proliferation and the acquisition of an invasive phenotype. Extracellular matrix …

Metastasis remains the leading cause of cancer lethality. The'seed/soil'hypothesis provides
the framework to explain this cancer phenomenon where the concept of organotropism has …