Replacement, reduction, and refinement of animal experiments in anticancer drug development: the contribution of 3D in vitro cancer models in the drug efficacy …
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
Challenges and prospects of patient-derived xenografts for cancer research
J Jin, K Yoshimura, M Sewastjanow-Silva, S Song… - Cancers, 2023 - mdpi.com
Simple Summary The patient-derived xenograft (PDX) model is the in vivo standard for
cancer research as a preclinical platform. Besides its merits, we describe the general …
cancer research as a preclinical platform. Besides its merits, we describe the general …
[HTML][HTML] Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer
The tumor microenvironment consists of diverse, complex etiological factors. The matrix
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …
Cancer Models on Chip: Paving the Way to Large‐Scale Trial Applications
Cancer kills millions of individuals every year all over the world (Global Cancer
Observatory). The physiological and biomechanical processes underlying the tumor are still …
Observatory). The physiological and biomechanical processes underlying the tumor are still …
3D-bioprinted cancer-on-a-chip: level-up organotypic in vitro models
Combinatorial conjugation of organ-on-a-chip platforms with additive manufacturing
technologies is rapidly emerging as a disruptive approach for upgrading cancer-on-a-chip …
technologies is rapidly emerging as a disruptive approach for upgrading cancer-on-a-chip …
Advancing tissue decellularized hydrogels for engineering human organoids
The extracellular matrix plays a critical role in bioinstructing cellular self‐assembly and
spatial (re) configuration processes that culminate in human organoids in vitro generation …
spatial (re) configuration processes that culminate in human organoids in vitro generation …
Targeting tumor-stromal interactions in pancreatic cancer: impact of collagens and mechanical traits
P Maneshi, J Mason, M Dongre… - Frontiers in Cell and …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst outcomes among cancers
with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of …
with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of …
Cancer-on-chip: a 3D model for the study of the tumor microenvironment
E Cauli, MA Polidoro, S Marzorati, C Bernardi… - Journal of Biological …, 2023 - Springer
The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …
3D collagen-nanocellulose matrices model the tumour microenvironment of pancreatic cancer
R Curvello, V Kast, MH Abuwarwar… - Frontiers in Digital …, 2021 - frontiersin.org
Three-dimensional (3D) cancer models are invaluable tools designed to study tumour
biology and new treatments. Pancreatic ductal adenocarcinoma (PDAC), one of the …
biology and new treatments. Pancreatic ductal adenocarcinoma (PDAC), one of the …
PDAC-on-chip for in vitro modeling of stromal and pancreatic cancer cell crosstalk
V Sgarminato, SL Marasso, M Cocuzza… - Biomaterials …, 2023 - pubs.rsc.org
Pancreatic ductal adenocarcinoma (PDAC) mainly develops in the head of the pancreas,
within the acino-ductal unit composed of acinar and ductal cells surrounded by pancreatic …
within the acino-ductal unit composed of acinar and ductal cells surrounded by pancreatic …