We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …

Lactose intolerance related to primary or secondary lactase deficiency is characterized by
abdominal pain and distension, borborygmi, flatus, and diarrhea induced by lactose in dairy …

In the songs and bubble feeding of humpback whales; in young killer whales learning to
knock a seal from an ice floe in the same way their mother does; and in the use of sea …

Ockham's razor, the principle of parsimony, states that simpler theories are better than
theories that are more complex. It has a history dating back to Aristotle and it plays an …

The evolution of phenotypic similarities between species, known as convergence, illustrates
that populations can respond predictably to ecological challenges. Convergence often …

Lactose intolerance refers to symptoms related to the consumption of lactose-containing
dairy foods, which are the most common source for this disaccharide. While four causes are …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

The genetic architecture of adaptive traits is of key importance to predict evolutionary
responses. Most adaptive traits are polygenic—ie, result from selection on a large number of …

The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

Genotype imputation is a statistical technique that is often used to increase the power and
resolution of genetic association studies. Imputation methods work by using haplotype …