All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …
F Portale, D Di Mitri - International Journal of Molecular Sciences, 2023 - mdpi.com
Natural killer cells (NK) are innate lymphocytes endowed with the ability to recognize and kill cancer cells. Consequently, adoptive transfer of autologous or allogeneic NK cells …
Tumour cell biomechanics has lately came to the fore as a disparate feature that fosters cancer development and progression. Tumour mechanosensing entails a mechanical …
Extracellular biophysical properties have particular implications for a wide spectrum of cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …
C Wu, S Dong, R Huang, X Chen - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer is the most prevalent cancer in women worldwide, and it exhibits a growing incidence. An increasing number of studies showed the complex …
In vitro three-dimensional models aim to reduce and replace animal testing and establish new tools for oncology research and the development and testing of new anticancer …
CA Horta, K Doan, J Yang - Current Opinion in Cell Biology, 2023 - Elsevier
The extracellular matrix (ECM) provides structural support for cells and mediates cell-stromal communications. In addition to ECM proteins, mechanical force exerted from the ECM …
A Purushothaman, M Mohajeri, TP Lele - Journal of Biological Chemistry, 2023 - ASBMB
Although cancer is a genetic disease, physical changes such as stiffening of the extracellular matrix also commonly occur in cancer. Cancer cells sense and respond to …