[HTML][HTML] Role of fibroblasts in wound healing and tissue remodeling on Earth and in space

F Cialdai, C Risaliti, M Monici - Frontiers in bioengineering and …, 2022 - frontiersin.org
Wound healing (WH) and the role fibroblasts play in the process, as well as healing
impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We …

[HTML][HTML] The state of the art of Piezo1 channels in skeletal muscle regeneration

A Bernareggi, A Bosutti, G Massaria… - International Journal of …, 2022 - mdpi.com
Piezo1 channels are highly mechanically-activated cation channels that can sense and
transduce the mechanical stimuli into physiological signals in different tissues including …

Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells

CJ Gallardo-Dodd, C Oertlin, J Record, RG Galvani… - Science …, 2023 - science.org
The next steps of deep space exploration are manned missions to Moon and Mars. For safe
space missions for crew members, it is important to understand the impact of space flight on …

[HTML][HTML] Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity

M ElGindi, J Sapudom, A Garcia Sabate… - npj Aging, 2023 - nature.com
Microgravity accelerates the aging of various physiological systems, and it is well
acknowledged that aged individuals and astronauts both have increased susceptibility to …

[HTML][HTML] Homo sapiens—A Species Not Designed for Space Flight: Health Risks in Low Earth Orbit and Beyond, Including Potential Risks When Traveling beyond the …

DA Hart - Life, 2023 - mdpi.com
Homo sapiens and their predecessors evolved in the context of the boundary conditions of
Earth, including a 1 g gravity and a geomagnetic field (GMF). These variables, plus others …

[HTML][HTML] Fibroblast differentiation and matrix remodeling impaired under simulated microgravity in 3D cell culture model

J Sapudom, M ElGindi, M Arnoux, N Drou… - International journal of …, 2021 - mdpi.com
Exposure to microgravity affects astronauts' health in adverse ways. However, less is known
about the extent to which fibroblast differentiation during the wound healing process is …

[HTML][HTML] The Effects of Combined Exposure to Simulated Microgravity, Ionizing Radiation, and Cortisol on the In Vitro Wound Healing Process

WE Radstake, K Gautam, S Miranda, R Vermeesen… - Cells, 2023 - mdpi.com
Human spaceflight is associated with several health-related issues as a result of long-term
exposure to microgravity, ionizing radiation, and higher levels of psychological stress …

[HTML][HTML] 3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome

M ElGindi, J Sapudom, P Laws… - Cellular and Molecular …, 2022 - Springer
Human space travel and exploration are of interest to both the industrial and scientific
community. However, there are many adverse effects of spaceflight on human physiology. In …

[HTML][HTML] The impact of microgravity on immunological states

J Hicks, M Olson, C Mitchell, CM Juran, AM Paul - Immunohorizons, 2023 - journals.aai.org
As we explore other planetary bodies, astronauts will face unique environmental and
physiological challenges. The human immune system has evolved under Earth's …

[HTML][HTML] Spaceflight stressors and skin health

WE Radstake, B Baselet, S Baatout, M Verslegers - Biomedicines, 2022 - mdpi.com
Traveling to space puts astronauts at risk of developing serious health problems. Of
particular interest is the skin, which is vitally important in protecting the body from harmful …