3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate
Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …
3D printing biomimetic materials and structures for biomedical applications
Over millions of years of evolution, nature has created organisms with overwhelming
performances due to their unique materials and structures, providing us with valuable …
performances due to their unique materials and structures, providing us with valuable …
[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
MA Heinrich, AMRH Mostafa, JP Morton… - Advanced drug delivery …, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
3D in vitro M2 macrophage model to mimic modulation of tissue repair
Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis
H Zhou, M Wang, Y Zhang, Q Su, Z Xie… - Cancer …, 2022 - Wiley Online Library
Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
Natural and synthetic biomaterials for engineering multicellular tumor spheroids
The lack of in vitro models that represent the native tumor microenvironment is a significant
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …
Designer self‐assembling peptide hydrogels to engineer 3D cell microenvironments for cell constructs formation and precise oncology remodeling in ovarian cancer
Z Yang, H Xu, X Zhao - Advanced Science, 2020 - Wiley Online Library
Designer self‐assembling peptides form the entangled nanofiber networks in hydrogels by
ionic‐complementary self‐assembly. This type of hydrogel has realistic biological and …
ionic‐complementary self‐assembly. This type of hydrogel has realistic biological and …
May the force be with you (or not): The immune system under microgravity
All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …
Due to the increase of crewed space flights in recent years, it is vital to understand how the …
Modeling adipogenesis: current and future perspective
Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body.
Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells …
Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells …
Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells
Extracellular matrix stiffening of breast tissues has been clinically correlated with malignant
transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase …
transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase …