Association of collagen deep learning classifier with prognosis and chemotherapy benefits in stage II‐III colon cancer

W Jiang, H Wang, W Chen, Y Zhao… - Bioengineering & …, 2023 - Wiley Online Library
The current tumor‐node‐metastasis staging system does not provide sufficient prognostic
prediction or adjuvant chemotherapy benefit information for stage II‐III colon cancer (CC) …

A nomogram based on a collagen feature support vector machine for predicting the treatment response to neoadjuvant chemoradiotherapy in rectal cancer patients

W Jiang, M Li, J Tan, M Feng, J Zheng, D Chen… - Annals of Surgical …, 2021 - Springer
Background The relationship between collagen features (CFs) in the tumor
microenvironment and the treatment response to neoadjuvant chemoradiotherapy (nCRT) is …

Cancer cell migration in collagen-hyaluronan composite extracellular matrices

SRU Veettil, D Hwang, J Correia, MD Bartlett… - Acta Biomaterialia, 2021 - Elsevier
Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates
in cancer growth and invasiveness. While the molecular weight (MW) dependent properties …

Three-dimensional in vitro biomimetic model of neuroblastoma using collagen-based scaffolds

C Gallagher, C Murphy, G Kelly, FJ O'Brien… - JoVE (Journal of …, 2021 - jove.com
Neuroblastoma is the most common extracranial solid tumor in children, accounting for 15%
of overall pediatric cancer deaths. The native tumor tissue is a complex three-dimensional …

Recent advances in regenerative tissue fabrication: Tools, materials, and microenvironment in hierarchical aspects

MC Ratri, AI Brilian, A Setiawati… - Advanced …, 2021 - Wiley Online Library
As part of regenerative medicine, artificial, hierarchical tissue engineering is a favorable
approach to satisfy the needs of patients for new tissues and organs to replace those with …

Biomimetic tissue models reveal the role of hyaluronan in melanoma proliferation and invasion

J Sapudom, KT Nguyen, S Martin, T Wippold… - Biomaterials …, 2020 - pubs.rsc.org
Interactions of hyaluronan (HA) and tumor and stromal cells are highly discussed as one of
the major contributors in tumor progression and metastasis. The balance of HA in the tissue …

Matrix‐Bound Hyaluronan Molecular Weight as a Regulator of Dendritic Cell Immune Potency

BC Quartey, J Sapudom, M ElGindi… - Advanced …, 2024 - Wiley Online Library
Hyaluronic acid (HA) is a glycosaminoglycan in the extracellular matrix with
immunoregulatory properties depending on its molecular weight (MW). However, the impact …

N6‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion

W Wang, Y He, L Wu, LL Zhai, LJ Chen… - Cancer …, 2023 - Wiley Online Library
Pancreatic cancer (PC) is a deadly disease, and its post‐transcriptional gene regulation
mechanism remains unclear. The abundant extracellular matrix (ECM) in PC plays an …

Identification of different types of tumors based on photoacoustic spectral analysis: preclinical feasibility studies on skin tumors

M Zhang, L Wen, C Zhou, J Pan, S Wu… - Journal of …, 2023 - spiedigitallibrary.org
Significance Collagen and lipid are important components of tumor microenvironments
(TME) and participates in tumor development and invasion. It has been reported that …

Biomaterial strategies to replicate gynecological tissue

I Cadena, A Chen, A Arvidson, KC Fogg - Biomaterials Science, 2021 - pubs.rsc.org
Women's health is an important and understudied area of research. The current standard of
care for many gynecological diseases such as cancer or autoimmune-linked disorders such …