A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

Oxidative stress is a status of imbalance between oxidants and antioxidants, resulting in
molecular damage and interruption of redox signaling in an organism. Indeed, oxidative …

The distinguishing pathogenic features of neurodegenerative diseases include
mitochondrial dysfunction and derived reactive oxygen species generation. The neural …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

The pathology of Alzheimer's disease (AD) is highly correlated with obesity-induced insulin
resistance. Resveratrol (Res) is a natural phenol that demonstrates a neuroprotective effect …

Control of excessive mitochondrial oxidative stress could provide new targets for both
preventive and therapeutic interventions in the treatment of chronic inflammation or any …

The blood–brain barrier (BBB) is a physical structure whose main function is to strictly
regulate access to circulating compounds into the central nervous system (CNS). Vegetable …