Hydrogels: properties and applications in biomedicine

TC Ho, CC Chang, HP Chan, TW Chung, CW Shu… - Molecules, 2022 - mdpi.com
Hydrogels are crosslinked polymer chains with three-dimensional (3D) network structures,
which can absorb relatively large amounts of fluid. Because of the high water content, soft …

Spheroid engineering in microfluidic devices

A Tevlek, S Kecili, OS Ozcelik, H Kulah, HC Tekin - ACS omega, 2023 - ACS Publications
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …

3D modeling in cancer studies

OE Atat, Z Farzaneh, M Pourhamzeh, F Taki… - Human Cell, 2022 - Springer
The tumor microenvironment contributes significantly to tumor initiation, progression, and
resistance to chemotherapy. Much of our understanding of the tumor and its …

Experimental in vitro, ex vivo and in vivo models in prostate cancer research

V Sailer, G von Amsberg, S Duensing, J Kirfel… - Nature Reviews …, 2023 - nature.com
Androgen deprivation therapy has a central role in the treatment of advanced prostate
cancer, often causing initial tumour remission before increasing independence from signal …

Chitosan and pectin hydrogels for tissue engineering and in vitro modeling

G Morello, G De Iaco, G Gigli, A Polini, F Gervaso - Gels, 2023 - mdpi.com
Hydrogels are fascinating biomaterials that can act as a support for cells, ie, a scaffold, in
which they can organize themselves spatially in a similar way to what occurs in vivo …

Smart hydrogels meet carbon nanomaterials for new frontiers in medicine

S Adorinni, P Rozhin, S Marchesan - Biomedicines, 2021 - mdpi.com
Carbon nanomaterials include diverse structures and morphologies, such as fullerenes,
nano-onions, nanodots, nanodiamonds, nanohorns, nanotubes, and graphene-based …

A thermo-sensitive chitosan/pectin hydrogel for long-term tumor spheroid culture

G Morello, A Quarta, A Gaballo, L Moroni, G Gigli… - Carbohydrate …, 2021 - Elsevier
Hydrogels represent a key element in the development of in vitro tumor models, by
mimicking the typical 3D tumor architecture in a physicochemical manner and allowing the …

Manganese/iron-based nanoprobes for photodynamic/chemotherapy combination therapy of tumor guided by multimodal imaging

S Fan, Y Zhang, H Tan, C Xue, Y He, X Wei, Y Zha… - Nanoscale, 2021 - pubs.rsc.org
Early diagnosis of tumors is crucial in selecting appropriate treatment options to achieve the
desired therapeutic effect, but it is difficult to accurately diagnose cancer by a single imaging …

Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research

T Ferreira, A Gama, F Seixas, AI Faustino-Rocha… - Veterinary …, 2023 - mdpi.com
Simple Summary Breast cancer research is frequently performed using a variety of models,
including animal models, in an attempt to provide information that can be translated into …

Comparison of Radiation response between 2D and 3D cell culture models of different human Cancer cell lines

J Raitanen, B Barta, M Hacker, D Georg, T Balber… - Cells, 2023 - mdpi.com
Radiation therapy is one of the most effective tools in cancer therapy. However, success
varies individually, necessitating improved understanding of radiobiology. Three …