Human neuronal maturation comes of age: cellular mechanisms and species differences

JL Wallace, AA Pollen - Nature Reviews Neuroscience, 2024 - nature.com
The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …

Therapeutic supramolecular polymers: Designs and applications

H Wang, J Mills, B Sun, H Cui - Progress in Polymer Science, 2023 - Elsevier
The self-assembly of low-molecular-weight building motifs into supramolecular polymers
has unlocked a new realm of materials with distinct properties and tremendous potential for …

Tunable hydrogel viscoelasticity modulates human neural maturation

JG Roth, MS Huang, RS Navarro, JT Akram… - Science …, 2023 - science.org
Human-induced pluripotent stem cells (hiPSCs) have emerged as a promising in vitro model
system for studying neurodevelopment. However, current models remain limited in their …

Facile In Situ Assembly of Nanofibers within Three-Dimensional Porous Matrices with Arbitrary Characteristics for Creating Biomimetic Architectures

L Fan, Z Cai, J Zhao, X Wang, JL Li - Nano Letters, 2023 - ACS Publications
It is challenging to recapitulate the natural extracellular matrix's hierarchical
nano/microfibrous three-dimensional (3D) structure with multilevel pores, good mechanical …

Maturing differentiated human pluripotent stem cells in vitro: methods and challenges

D Ottaviani, M Ter Huurne, DA Elliott, M Bellin… - …, 2023 - journals.biologists.com
Human pluripotent stem cells (hPSCs), derived from individuals or genetically modified with
disease-related mutations and variants, have revolutionised studies of human disease …

Enhanced neuron growth and electrical activity by a supramolecular netrin-1 mimetic nanofiber

CS Smith, Z Álvarez, R Qiu, IR Sasselli, T Clemons… - ACS …, 2023 - ACS Publications
Neurotrophic factors are essential not only for guiding the organization of the developing
nervous system but also for supporting the survival and growth of neurons after traumatic …

Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids

Z Sun, Z Chen, M Yin, X Wu, B Guo, X Cheng, R Quan… - Cell Stem Cell, 2024 - cell.com
Neonatal spinal cord tissues exhibit remarkable regenerative capabilities as compared to
adult spinal cord tissues after injury, but the role of extracellular matrix (ECM) in this process …

Antiviral fibrils of self-assembled peptides with tunable compositions

J Dodd-o, A Roy, Z Siddiqui, R Jafari, F Coppola… - Nature …, 2024 - nature.com
The lasting threat of viral pandemics necessitates the development of tailorable first-
response antivirals with specific but adaptive architectures for treatment of novel viral …

An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis

KM Au, JE Wilson, JPY Ting, AZ Wang - Nature Biomedical …, 2023 - nature.com
As a chronic autoinflammatory condition, ulcerative colitis is often managed via systemic
immunosuppressants. Here we show, in three mouse models of established ulcerative …

Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

JA Ortega, GP Soares de Aguiar… - Wiley …, 2024 - Wiley Online Library
The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …