Artificial intelligence aids in development of nanomedicines for cancer management

P Tan, X Chen, H Zhang, Q Wei, K Luo - Seminars in cancer biology, 2023 - Elsevier
Over the last decade, the nanomedicine has experienced unprecedented development in
diagnosis and management of diseases. A number of nanomedicines have been approved …

[HTML][HTML] Emerging applications of nanotechnology in healthcare and medicine

S Malik, K Muhammad, Y Waheed - Molecules, 2023 - mdpi.com
Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the
applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There …

[HTML][HTML] Method of the year: long-read sequencing

V Marx - Nature Methods, 2023 - nature.com
Method of the year: long-read sequencing | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

[HTML][HTML] Systematic comparison of tools used for m6A mapping from nanopore direct RNA sequencing

ZD Zhong, YY Xie, HX Chen, YL Lan, XH Liu… - Nature …, 2023 - nature.com
Abstract N6-methyladenosine (m6A) has been increasingly recognized as a new and
important regulator of gene expression. To date, transcriptome-wide m6A detection primarily …

EagleC: A deep-learning framework for detecting a full range of structural variations from bulk and single-cell contact maps

X Wang, Y Luan, F Yue - Science Advances, 2022 - science.org
The Hi-C technique has been shown to be a promising method to detect structural variations
(SVs) in human genomes. However, algorithms that can use Hi-C data for a full-range SV …

Advances in nucleic acid amplification techniques (NAATs): COVID-19 point-of-care diagnostics as an example

T Kang, J Lu, T Yu, Y Long, G Liu - Biosensors and Bioelectronics, 2022 - Elsevier
Achieving superhigh sensitivity is the ultimate goal for bio-detection in modern analytical
science and life science. Among variable signal amplification strategies, nucleic acid …

[HTML][HTML] In vivo hypermutation and continuous evolution

RS Molina, G Rix, AA Mengiste, B Álvarez… - Nature Reviews …, 2022 - nature.com
Directed evolution has revolutionized biomolecular engineering by applying cycles of
mutation, amplification and selection to genes of interest (GOIs). However, classical directed …

[HTML][HTML] Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 …

TB Johannesen, C Munkstrup, SM Edslev… - …, 2023 - eurosurveillance.org
A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly
expanding throughout Denmark since late 2022 and now accounts for 30% of the new …

[HTML][HTML] Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas

Y Ren, Z Huang, L Zhou, P Xiao, J Song, P He… - Nature …, 2023 - nature.com
Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal
brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors …

[HTML][HTML] Benchmarking of Nanopore R10. 4 and R9. 4.1 flow cells in single-cell whole-genome amplification and whole-genome shotgun sequencing

Y Ni, X Liu, ZM Simeneh, M Yang, R Li - Computational and Structural …, 2023 - Elsevier
Third-generation sequencing can be used in human cancer genomics and epigenomic
research. Oxford Nanopore Technologies (ONT) recently released R10. 4 flow cell, which …