Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - ASPET
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Resmetirom, the first approved drug for the management of metabolic dysfunction-associated steatohepatitis: trials, opportunities, and challenges

M Kokkorakis, C Boutari, MA Hill… - Metabolism …, 2024 - metabolismjournal.com
Over the past decade, there have been several guideline updates for the diagnosis and
management of non-alcoholic fatty liver disease (NAFLD), which is the most common …

Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical …

M Kokkorakis, A Katsarou, N Katsiki, CS Mantzoros - Metabolism, 2023 - Elsevier
The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study

L Valenzuela-Vallejo, P Chrysafi, M Kouvari… - Metabolism, 2023 - Elsevier
Background The role of metabolic/inflammatory hormonal systems in metabolic dysfunction
associated steatotic liver disease (MASLD) remains to be fully elucidated. Purpose To report …

Recent research advances in metabolism, clinical and experimental

C Boutari, M Kokkorakis, K Stefanakis… - Metabolism, 2023 - Elsevier
Metabolic disorders such as obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and non-
alcoholic fatty liver disease (NAFLD)–henceforth named metabolic dysfunction-associated …

Sodium-glucose co-transporter 2 inhibitors and Sarcopenia: a controversy that must be solved

B Afsar, RE Afsar - Clinical Nutrition, 2023 - Elsevier
Diabetes mellitus is a risk factor for muscle loss and sarcopenia. Sodium-glucose co-
transporter 2 inhibitors (SGLT2i) or “gliflozins” are one of the newest anti-hyperglycemic …

Prevalence of steatotic liver disease and associated fibrosis in the United States: Results from NHANES 2017-March 2020

N Luo, X Zhang, J Huang, H Chen… - Journal of …, 2024 - journal-of-hepatology.eu
To the Editor: 15 Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver
disorder 16 globally, affecting approximately one-fourth of the world's population [1] …

The association of metabolic dysfunction-associated steatotic liver disease (MASLD) with the risk of myocardial infarction: a systematic review and meta-analysis

Q Lv, H Zhao - Annals of medicine, 2024 - Taylor & Francis
Objective While studies have documented how metabolic dysfunction-associated steatotic
liver disease (MASLD) can contribute to cardiovascular disease (CVD), whether MASLD is …

Circulating total and H-specific GDF15 levels are elevated in subjects with MASLD but not in hyperlipidemic but otherwise metabolically healthy subjects with obesity

C Boutari, K Stefanakis, S Simati… - Cardiovascular …, 2024 - Springer
Background Growth differentiation factor 15 (GDF15) is a mitokine, the role of which, total or
H-specific, in modulating energy metabolism and homeostasis in obesity-related diseases …

[HTML][HTML] From NAFLD to MASLD: when metabolic comorbidity matters

S Hong, L Sun, Y Hao, P Li, Y Zhou, X Liang, J Hu… - Annals of …, 2024 - Elsevier
Abstract Introduction and Objectives In a recent development, a cohort of hepatologists has
proposed altering the nomenclature of non-alcoholic fatty liver disease (NAFLD) to …